Prediction of end-dialysis serum sodium concentration in severely hyponatremic kidney failure patients undergoing conventional hemodialysis using sodium kinetic equation

Abstract Background and Objectives Conventional hemodialysis (HD) for kidney failure patients with severe hyponatremia may be complicated by rapid correction of hyponatremia, which increases the risk osmotic demyelination syndrome. A simple sodium kinetic equation was effective in prediction end-dialysis serum Na + severely hyponatremic patient treated continuous venovenous hemofiltration, but not tested conventional HD. The aim this study to assess validity when used Methods Twenty HD sessions were delivered 12 (serum < 120 mEq/L). target change 4 mEq/L. D .t/V that obtained predetermined according monitored real time online clearance monitoring software embedded dialysis machine. session terminated once achieved. Results mean observed predicted 119.80 ± 3.42 mEq/L 119.45 3.12 mEq/L, respectively. Bland–Altman plot analysis revealed a difference SD 0.33 1.26 95% limits agreement − 2.13 2.83. imprecision 2.52 small clinically insignificant indicate good between . Conclusion hyponatremia.